Optimisation of distributed feedback laser biosensors

A new integrated optical sensor chip is proposed, based on a modified distributed- feedback (DFB) semiconductor laser. The semiconductor layers of different refractive indices that comprise a laser form the basis of a waveguide sensor, where changes in the refractive index of material at the surface are sensed via changes in the evanescent field of the lasing mode. In DFB lasers, laser oscillation occurs at the Bragg wavelength. Since this is sensitive to the effective refractive index of the optical mode, the emission wavelength is sensitive to the index of a sample on the waveguide surface. Hence, lasers are modelled as planar waveguides and the effective index of the fundamental transverse electric mode is calculated as a function of index and thickness of a thin surface layer using the beam propagation method. We find that an optimised structure has a thin upper cladding layer of ~0.15 mum, which according to this model gives detection limits on test layer index and thickness resolution of 0.1 and 1.57 nm, respectively, a figure which may be further improved using two lasers in an interferometer-type configuration

An Investigation of the Adsorption Characteristics of 5'ATP and 5'AMP onto the Surface of Caso4 x 2H2O

A model has been proposed in which solid surfaces can act as a site for cataletic activity of condensation reactions for certain biomolecules. From this model, the adsorption characteristics of 5'ATP and 5'AMP onto the surface of CaSO4.2H2O was chosen for study. It has been proven that 5'ATP and 5'AMP do adsorb onto the surface of CaSO4. Studies were then made to determine the dependence of absorption versus time, concentration, ionic strength and pH. It was found that the adsorption of the nucleotides is highly pH dependent, primarily determined by the phosphate acid groups of the nucleic acid molecule. From this investigation, the data obtained is discussed in relation to the model for the prebiotic earth

An investigation of the adsorption characteristics of 5 prime ATP and 5 prime AMP onto the surface of CaSO sub 4 x 2H sub 2 O

A model has been proposed (Lahev and Chans, 1982) in which solid surfaces can act as a site for catalytic activity of condensation reactions for certain biomolecules. From this model, the adsorption characteristics of 5'ATP and 5'AMP onto the surface of CaSO4 2H2O was chosen for study. It has been proven that 5'ATP and 5'AMP do adsorb onto the surface of CaSO4. Studies were then made to determine the dependence of adsorption versus time, concentration, ionic strength and pH. It was found that the adsorption of the nucleotides is highly pH dependent, primarily determined by the phosphate acid groups of the nucleic acid molecule. From this investigation, the data obtained are discussed in relation to the model for the prebiotic earth

Implementable Wireless Access for B3G Networks - III: Complexity Reducing Transceiver Structures

This article presents a comprehensive overview of some of the research conducted within Mobile VCE’s Core Wireless Access Research Programme,1 a key focus of which has naturally been on MIMO transceivers. The series of articles offers a coherent view of how the work was structured and comprises a compilation of material that has been presented in detail elsewhere (see references within the article). In this article MIMO channel measurements, analysis, and modeling, which were presented previously in the first article in this series of four, are utilized to develop compact and distributed antenna arrays. Parallel activities led to research into low-complexity MIMO single-user spacetime coding techniques, as well as SISO and MIMO multi-user CDMA-based transceivers for B3G systems. As well as feeding into the industry’s in-house research program, significant extensions of this work are now in hand, within Mobile VCE’s own core activity, aiming toward securing major improvements in delivery efficiency in future wireless systems through crosslayer operation

Dual-frequency GPS survey for validation of a regional DTM and for the generation of local DTM data for sea-level rise modelling in an estuarine salt marsh

Global average temperatures have risen by an average of 0.07°C per decade over the last 100 years, with a warming trend of 0.13°C per decade over the last 50 years. Temperatures are predicted to rise by 2°C - 4.4°C by 2100 leading to global average sealevel rise (SLR) of 2 – 6mm per year (20 – 60cms in total) up to 2100 (IPCC 2007) with impacts for protected coastal habitats in Ireland. Estuaries are predominantly sedimentary environments, and are characterised by shallow coastal slope gradients, making them sensitive to even modest changes in sea-level. The Shannon estuary is the largest river estuary in Ireland and is designated as a Special Area of Conservation (SAC) under the EU Habitats Directive (EU 1992) providing protection for listed habitats within it, including estuarine salt marsh. Trends in Shannon estuary tidal data from 1877 – 2004 suggest an average upward SLR trend of 4 - 5mm/yr over this period. A simple linear extension of this historical trend would imply that local SLR will be in the region of 40 - 45cm by 2100. However, this may underestimate actual SLR for the estuary by 2100, since it takes no account of predicted climate-driven global SLR acceleration (IPCC 2007) up to 2100

Prawn Shell Chitosan Has Anti-Obesogenic Properties, Influencing Both Nutrient Digestibility and Microbial Populations in a Pig Model

This study was supported financially (Grant-Aid Agreement No. MFFRI/07/01) under the Sea Change Strategy with the support of the Marine Institute and the Department of Agriculture, Food and the Marine, funded under the National Development Plan 2007–2013.peer-reviewedThe potential of natural products to prevent obesity have been investigated, with evidence to suggest that chitosan has anti-obesity effects. The current experiment investigated the anti-obesity potential of prawn shell derived chitosan on a range of variables relevant to obesity in a pig model. The two dietary treatment groups included in this 63 day study were: T1) basal diet and T2) basal diet plus 1000 ppm chitosan (n = 20 gilts per group (70 ± 0.90 kg). The parameter categories which were assessed included: performance, nutrient digestibility, serum leptin concentrations, nutrient transporter and digestive enzyme gene expression and gut microbial populations. Pigs offered chitosan had reduced feed intake and final body weight (P< 0.001), lower ileal digestibility of dry matter (DM), gross energy (GE) (P< 0.05) and reduced coefficient of apparent total tract digestibility (CATTD) of gross energy and nitrogen (P<0.05) when compared to the basal group. Fatty acid binding protein 2 (FABP2) gene expression was down-regulated in pigs offered chitosan (P = 0.05) relative to the basal diet. Serum leptin concentrations increased (P< 0.05) in animals offered the chitosan diet compared to pigs offered the basal diet. Fatness traits, back-fat depth (mm), fat content (kg), were significantly reduced while lean meat (%) was increased (P<0.05) in chitosan supplemented pigs. Pigs offered chitosan had decreased numbers of Firmicutes in the colon (P <0.05), and Lactobacillus spp. in both the caecum (P <0.05) and colon (P <0.001). Bifidobacteria populations were increased in the caecum of animals offered the chitosan diet (P <0.05). In conclusion, these findings suggest that prawn shell chitosan has potent anti-obesity/body weight control effects which are mediated through multiple biological systems in vivo.This study was supported financially (Grant-Aid Agreement No. MFFRI/07/01) under the Sea Change Strategy with the support of the Marine Institute and the Department of Agriculture, Food and the Marine, funded under the National Development Plan 2007–2013

Intra-assessor consistency in question answering

In this paper we investigate the consistency of answer assessment in a complex question answering task examining features of assessor consistency, types of answers and question type